Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Repurposing of carvedilol to alleviate bleomycin-induced lung fibrosis in rats: Repressing of TGF-β1/α-SMA/Smad2/3 and STAT3 gene expressions
Faculty
Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Heba Ahmed Hassan Hanafi
Staff Zu Site
Abstract In Staff Site
Journal:
Life Sciences Elsevier
Volume:
324
Keywords :
Repurposing , carvedilol , alleviate bleomycin-induced lung fibrosis
Abstract:
Idiopathic pulmonary fibrosis (IPF) is the most widely studied interstitial lung disease. IPF eventually leads to respiratory insufficiency, lung cancer, and death. Carvedilol (CAR) is a third-generation β-adrenergic receptor antagonist with an α1-blocking effect. CAR demonstrates antifibrotic activities in various experimental models of organ fibrosis. Aims: This work is designed to explore the possible alleviating effects of CAR on bleomycin (BLM)-induced lung fibrosis in rats. Main methods: The BLM rat model of lung fibrosis was achieved by intratracheal delivery of a single dose of 5 mg/kg of BLM. Seven days following BLM injection, either prednisolone or CAR was orally administered at doses of 10 mg/kg once daily for 21 days to the rats. The actions of CAR were evaluated by lung oxidant/antioxidant parameters, protein concentration and total leucocyte count (TLC) in bronchoalveolar lavage fluid (BALF), fibrosis regulator-related genes along with the coexistent lung histological changes. Key findings: CAR effectively decreased lung malondialdehyde level, increased superoxide dismutase activity, declined both protein concentration and TLC in BALF, downregulated TGF-β1/α-SMA/Smad2/3 and STAT3 gene expressions, and repaired the damaged lung tissues. Significance: CAR conferred therapeutic potential against BLM-induced lung fibrosis in rats, at least in part, to its antioxidant, anti-inflammatory, and antifibrotic activities. CAR could be utilized as a prospective therapeutic option in patients with lung fibrosis in clinical practice.
Author Related Publications
Heba Ahmed Hassan Hanafi, "Crocin averts functional and structural rat hepatic disturbances induced by copper oxide nanoparticles", Oxford University Press, 2022
More
Heba Ahmed Hassan Hanafi, "Comparative effectiveness of methylene blue versus intravenous lipid emulsion in a rodent model of amlodipine toxicity", TAYLOR & FRANCIS LTD, 2019
More
Heba Ahmed Hassan Hanafi, "Neuroprotective Effect of ADIOL against Lithium Pilocarpine Induced-Seizures, Behavioral Changes and Cognitive Deficits in Male Mice", . Zagazig University Medical Journal 2019;25(1, 2018
More
Heba Ahmed Hassan Hanafi, "Neuroprotective Effect of ADIOL against Lithium Pilocarpine Induced-Seizures, Behavioral Changes and Cognitive Deficits in Male Mice", . Zagazig University Medical Journal 2019;25(1, 2018
More
Heba Ahmed Hassan Hanafi, "Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats", springer nature, 2023
More
Department Related Publications
Amal Alsayed Sehata Morssi, "20. معدلات تدفق الدم بالنسيج الضام للمبيض باستخدام الدوبلر ذو الطاقة ثلاثى الابعاد وعامل النمو للخلايا المبطنة للاوعية الدموية في متلازمة تكيس المبيض عقب تثقيب المبيض بمنظار البطن ", لايوجد, 1900
More
Diab Ahmed Radwan, "ارتباط عامل نمو العصب و الانترلوكين -4 و-5 في حدوث الربو الشعبى و دورهم فى تنشيط خلايا الاوزينوفيل", لايوجد, 1900
More
Diab Ahmed Radwan, "تاثير ثيوسلفات الصوديوم و الميلاتونين علي الاثار السميه لعقار السيزبلاتين على الاذن و الكلى و خطوره الاكسده فى الجرزان البيضاء البالغه", لايوجد, 1900
More
Sami Hassan Ibrahim, "دور فيروس الالتهاب الكبدي س في حدوث مرض الرثيان المفصلي.", لايوجد, 1900
More
Sami Hassan Ibrahim, "اهميه قياس عامل نمو خلايا بطانه الاوعيه الدمويه في مصل دم مرضي سرطان الكبد", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف