This study explores the application of abrasive waterjet drilling (AWJD) for varied patterns of GF/Al mesh hybrid composites (neat glass NG, AG: Al in the exterior surface, and GA: Al in the center). Key parameters such as jet pressure (P), standoff distance (S), and traverse speed (V) are systematically varied, influencing material removal rate (MRR), hole taper ratio ( ), and roundness error ( ). Employing a Taguchi approach with an L9 design. It was indicated that the optimal conditions for maximum MRR are (P: 150 MPa, S: 2 mm, and V: 900 mm/min). V and S are the main influential parameters on and . Gray relational analysis (GRA) is employed for simultaneous optimization, enhancing drilling performance. The optimal parameters P of 150 MPa, S of 2 mm, and V of 300 mm/min are determined. Validation trials confirm the effectiveness of the determined parameters. A robust multiple regression equation is formulated, providing a predictive model that aligns closely with experimental observations.