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Glucose lowering treatment in patients with coronary artery disease is prognostically important not only in established but also in newly detected diabetes mellitus: a report from the Euro Heart Survey on Diabetes and the Heart
Faculty
Medicine
Year:
2007
Type of Publication:
ZU Hosted
Pages:
Authors:
Aly Mohamed Abdelrahman Saad
Staff Zu Site
Abstract In Staff Site
Journal:
European Heart Journal Oxford academic
Volume:
2
Keywords :
Glucose lowering treatment , patients with coronary
Abstract:
Abstract Aims Glucose lowering (GL) therapy in patients with diabetes mellitus (DM) and coronary artery disease (CAD) is prognostically important. This report from the Euro Heart Survey on Diabetes and the Heart describes present practice in relation to 1 year prognosis. Methods and results The survey enrolled 4676 patients with CAD from 110 centres out of whom 1425 had known and 452 newly detected DM. The impact of different GL modalities on cardiovascular events (CVE: death, myocardial infarction, or stroke) was followed. Insulin treated patients with known DM (n = 378) had an adjusted 1 year hazard ratio (HR) for mortality of 2.23 (95% CI 1.24–4.03; P = 0.006) and for CVE of 1.27 (95% CI 0.85–1.87; P = 0.230) compared with those on oral GL drugs (n = 675). Of patients with newly detected DM 77 (17%) were started on GL drugs. None of them died compared with 25 (P = 0.002) among those without such treatment and their 1 year CVE HR was 0.22 (95% CI 0.05–0.97; P = 0.041) compared with untreated subjects. Conclusion Insulin therapy may relate to a more serious prognosis in CAD-patients with DM. There was a pronounced decrease in cardiovascular events in patients with newly detected DM prescribed GL drugs compared with those not receiving such treatment.
Author Related Publications
Aly Mohamed Abdelrahman Saad, "The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe The Euro Heart Survey on diabetes and the heart", Elsevier, 2004
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Aly Mohamed Abdelrahman Saad, "Treatment and Health Status in Patients with Proven Coronary Artery Disease, but Ineligible for Revascularization. A Report from the Euro Heart Survey on Revascularization", Sage, 2006
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Aly Mohamed Abdelrahman Saad, "Pharmacological treatment and perceived health status during 1-year follow up in patients diagnosed with coronary artery disease, but ineligible for revascularization: Results from the Euro Heart Survey on coronary revascularization", Sage, 2006
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Aly Mohamed Abdelrahman Saad, "A 1-year follow up in patients diagnosed with coronary artery disease, but ineligible for revascularization. Results from The Euro Heart Survey on Coronary Revascularization", Oxford University Press, 2006
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Aly Mohamed Abdelrahman Saad, "Atrial fibrillation management: a prospective survey in ESC Member Countries", Oxford University Press, 2005
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Ahmed Shafea Mahmoud Morsy, "قيمه سمك الطانه والطبقة الوسطي للشريان السباتي والفخذي كعامل غير نافذ للتنبؤ بمرض الشريان التاجي", مجلة القلب المصرية, 2001
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Tarek Abdelmoniem Abdelaziz, "Human C-reactive protein gene polymorphism andmetabolic syndrome are associated with premature coronary artery disease", Elsevier, 2013
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