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Oral proniosomal amitriptyline and liraglutide for management of diabetic neuropathy: Exceptional control over hyperglycemia and neuropathic pain
Faculty
Pharmacy
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Sally Kamel Abdelattef
Staff Zu Site
Abstract In Staff Site
Journal:
International Journal of Pharmaceutics Elsevier
Volume:
Keywords :
Oral proniosomal amitriptyline , liraglutide , management , diabetic neuropathy:
Abstract:
Exploitation of nanocarriers provides a compartment for enclosing drugs to protect them from degradation and potentiate their therapeutic efficiency. In the current study, amitriptyline- and liraglutide-loaded proniosomes were constructed for management of diabetic neuropathy, a serious complication associated with diabetes, that triggers spontaneous pain in patients and results in impaired quality of life. The developed therapeutic proniosomes were extensively characterized via dynamic light scattering, scanning electron microscopy, transmission electron microscopy, and Fourier transform-infrared spectroscopy. High entrapment efficiency could be attained for both drugs in the proniosomes, and the reconstituted amitriptyline- and liraglutide-loaded niosomes possessed spherical morphology and particle sizes of 585.3 nm and 864.4 nm, respectively. In a diabetic neuropathy rat model, oral administration of the developed amitriptyline- and liraglutide-loaded proniosomes significantly controlled blood glucose levels, reduced neuropathic pain, oxidative stress and inflammatory markers, and improved histological structure of the sciatic nerve as compared to the oral and subcutaneous administration of amitriptyline and liraglutide, respectively. Loading of the tricyclic antidepressant amitriptyline and the antidiabetic peptide liraglutide into proniosomes resulted in exceptional control over hyperglycemia and neuropathic pain, and thus could provide an auspicious delivery system for management of neuropathic pain and control of blood glucose levels.
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Sally Kamel Abdelattef, "Obesity and neurodegeneration: effect of a Mediterranean dietary pattern", Taylor & Francis Group, 2010
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Sally Kamel Abdelattef, "Long Noncoding RNA Function and Expression in Cancer", Springer-Verlag Berlin Heidelberg, 2011
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Sally Kamel Abdelattef, "Ablation of the Hypertension Candidate Gene ATP2B1 Results in Increased Blood Pressure and Cardiac Hypertrophic Remodeling", Lippincott Williams & Wilkins, 2014
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Sally Kamel Abdelattef, "PMCA1 Deletion Leads to Increased Blood Pressure and Cardiac Hypertrophy", BMJ Publishing Group Ltd and British Cardiovascular Society, 2014
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