Back ground: The anterior cruciate ligament injury is a serious injury often resulting in hospital admission for surgery. Assessment of anterior injury patients’ needs with anterior cruciate ligament is crucial to enable the development of better healthcare services and contribute towards a more holistic care, which will ultimately improve the quality of life for these patients. The study aimed to assess the needs of patients with anterior cruciate ligament knee injuries. Research design: A descriptive exploratory design was used in this study. Study subject: A purposive sample composed of 150 patients with anterior cruciate ligament injury attended orthopedic department and orthopedic outpatient clinic at Zagazig University Hospitals. Tools of data collection: Patients' assessment interviewing questionnaire, Patients' practices assessment questionnaire, and Patients' needs assessment questionnaire were used to collect data. Results: 64.7% of studied patients had age <40 years, 69.3% of patients were males, 62.7% of patients educated and 95.3% lived in rural area. 73.3% and respectively 94.0% of patients had satisfactory total knowledge and practice level. Moreover, 88.7% of patients their needs were highly affected by anterior cruciate ligament injury namely spiritual needs 82%, followed by socioeconomic needs 72.7%, psychological needs 71.3% & physical needs 39.3%, while only 11.3% of them had low affection. There was statistically significant positive correlation of patients' knowledge score with patients' practice score; patients' needs score, and patients' age. Conclusion: Majority of patients’ total needs were affected by anterior cruciate ligament injury. Recommendation: Provision training courses and rehabilitation programs with multidisplinary team for patients with anterior cruciate ligament injuries to help them meeting their needs.