Background: Burnout is a feeling of exhaustion that develops when an individual experiences too much pressure and too few sources of satisfaction, Psychiatric nurses experience a spacious range of stressful events Which affects physical and mental health. The aim of this study is to assess burnout, job characteristics and work place problems among staff nurses. Design: A descriptive correlational design was carried out. Setting: The study was conducted at El-Azazy Hospital for mental health in Abo Hammad city. Sample: A convenient sample of 100 nurses. Tools two tools were used to collect the study data: I) a structured interview questionnaire, and II) Maslach’s Burnout Inventory, Human Services Survey (MBI-HSS). Result the current study revealed that the mean age 29.0±5.1 years, (93%) were females, (57%) had less than 10 years of experience, While (95%) worked night shifts. Further, (78.0%) had problems with their families. While (30.0%) had problems with supervisors. Regarding burnout domains the highest level was to personal achievement (75.0%) followed by emotional exhaustion (59.0%), and (23.0%) of participants had depersonalization, while (19.0%) of them had high level of total burnout. There was a statistically significant relation between nurses’ total burnout and their problems with supervisors (p= o.oo3) and difficult transportation (P= 0.049). Multivariate analysis revealed that Small number of nurses per shift, problems with supervisors and difficult transportation were independent positive predictors of nurses total burnout (r=0.27) . Conclusion less than one-quarter of nurses had high level of total burnout. Also, problems with supervisors, peers and families due to over time were independent positive predictors of burnout. Recommendations regularly assessment for factors which increase levels of burnout among psychiatric nurses, Implementing interventions to deal effectively with burnout.