Background Nocturnal enuresis and its psychiatric comorbidities are important psychosocial problem. Aim of the work The aim is to study the prevalence and psychiatric comorbidities of nocturnal enuresis in 11 to13 years’ old children in Sharkia governorate. Subject and Method A random sample of school students aged 11 to 13 years old in Sharkia Governorate (N. 603) applied a strucured questionair searching for nocturnal enuresis. The cases having nocturnal enuresis (N.50) and non enuretic control group (51) applied Children's Manifest Anxiety Scale, Children Depression Inventory, Abuse and neglect scale for children. Results The overall prevalence was 8.29% (50/603), depression, anxiety and child abuse are significantly associated with nocturnal enuresis. Conclusion Our results with enuresis prevalence was comparable to other epidemiologic studies from various countries. Depression, anxiety and child abuse are more prevalent in enurtic child.