Telepsychiatry is a branch of telemedicine, Many published reviews have reported that telepsychiatry is comparable to face to face communications (Gajaria et al., 2015, Schutte et al., 2015, Hubley et al., 2016; Mazhari et al., 2019). However, it appears less reliable in the assessment of symptoms, such as emotional affect, that require visual observation of behavior (Jones et al., 2001), so, the efficacy of telepsychiatry to provide clinical psychiatric services to remote communities has yet to be definitively established (Tang et al., 2020). Nowadays with the development of COVID-19 pandemic and lockdown has become a must, which made the conventional psychiatric consultations difficult. This makes telepsychiatry a highly important method for patient’s care during the pandemic. The objective of this study was to compare the differences between face to face consultation and telepsychiatry from the patients’ perspective among an Egyptian sample of psychiatric patients during COVID-19 pandemic.