Background: Handicapped adolescents represent a significant portion of the world’spopulation and when compared to those without handicapping, are four times more probableto show fair or poor health. Aim: To assess the effect of educational programregardingreproductive health for handicapped adolescents in Sharkia Governorate. Subjects andMethods: It was a Quasi-experimental research design conducted at Al Noor and Al Amal schools in Sharkia Governorate. Purposive sample of ninety one students Blind andDeaf students from El-Amal School for Deaf and Hard for Hearing, and El-Nour School for Blindin Sharkia Governorate. Two tools were used; I.: A structured interviewsheet consistingof three parts: Part A; Demographic characteristics of the student. Part B; Student'sknowledge about reproductive health. Part C; Students’ menstrual history. II. Anobservational checklist to assess the student's self-report practice related to perineal care andpersonal hygiene regarding self-care during menstruation. Results: Generally, the samplewas deficient in pre-intervention except for their knowledge about abortion (81.3%), whileafter implementation of the educational program their knowledge was improved (P≤0.001). Additionally, regarding perineal care, 32.9% of handicapped adolescents (blind anddeaf) before intervention performed practice about perineal care, while after programimplementation the percentage was 82.1% and 86.7% at post-intervention and followuprespectively. Conclusion: This study results provided evidence that after application of theeducational intervention among handicapped adolescents (blind & deaf) at Al Noor andAl- Amal schools their knowledge, and practices about reproductive health improved inall components (p<0.001). Recommendation: Continuous health education programs shouldbeimplemented to increase handicapped adolescents’ about awareness of reproductive healthand menstrual hygiene practices