Background: Vaccines are vital in containing the COVID-19 epidemic and may be an essential tool in re-establishing "normalcy". The aim of the research was to investigate COVID‑19vaccination and predictors of vaccine hesitancy in Zagazig City. Research design: Adescriptive, cross-sectional design was used. Setting: The research was carried out in Zagazig CityandShaybah Village, Egypt. Subjects: A multistage systematic random sample involving997participants. Tools: Three questionnaires were used for data collection. I. The interviewquestionnaire consists of three tools: socio-demographic data, individual factors, and knowledgeabout the COVID-19 vaccine. II. Attitude assessment toward vaccine, and III. Applicationof theHealth Belief Model regarding COVID‑19 vaccination. Results: Only 10%of studied subjectshad taken the vaccine, and 24.2% of them had the intention to take the vaccine. In addition, 75.8% of them have vaccine hesitancy. Moreover, 54.0% of the studied subjects had adequateknowledge about the COVID-19 vaccine. The highest percentage of the studied subjects didnot know the difference between types of vaccine (40.9%). In addition, 60%of subjects havepositive attitudes about the COVID-19 vaccine. Furthermore, 40.3% of subjects have a neutral health belief model regarding the COVID-19 vaccine. Conclusion: The study presentedthat more than three-quarters of study participants had vaccine hesitancy. In general, more thanhalfof the subjects examined have enough knowledge. Moreover, three-fifths of themhave a positiveattitude toward the COVID-19 vaccine. Furthermore, two-fifths of the studied subjects hadaneutral health belief model about the COVID-19 vaccine. Recommendation: Health awarenessabout the importance of vaccines to protect from severe infection and deadly complicationsofCOVID- 19 virus.