Background: High levels of knowledge, and practice among mothers could support the needs of their children with epilepsy and intellectual disability. The aim of this study was to assess the effect of nursing intervention program on improving mothers' knowledge, practice, and attitudes toward management of their children with epilepsy and intellectual disability. A quasi-experimental design was applied in current study. A purposive sample composed of 71 mothers was recruited from three intellectual disability schools in Sharkia Governorate. Three tools were used: Tool (I): Mother’s knowledge about their children with epilepsy and intellectual disability. Tool (II): Mother’s practice observation checklist about their children with epilepsy and intellectual disability. Tool (III): Mother’s attitudes scale about their children with epilepsy and intellectual disability scale. Results: The majority of the mothers surveyed were married. Additionally, statistically significant increases in the mother's knowledge, practice, and attitudes were observed between pre- and post-sessions, with the total knowledge satisfied increasing from 2.8 % pre- to 100 % post-intervention and follow-up. The total positive attitudes increased from 56.3% in pre intervention, to 100% in post intervention and at follow up. Highly significant difference between scores of before fit, during fit, emergency, and after fit at pre, post- and follow-up at p<0.001. Conclusion: Current study revealed that the intervention efficiently improved mother's knowledge, attitude, and practice of epilepsy. Therefore, it is recommended that mothers should be equipped with all the necessary knowledge regarding children with epilepsy and intellectual disability either through a vast media campaign or by qualified health professionals.