Background: Smartphone addiction is a global widespread issue among young adults and it may have detrimental effects on their wellbeing. Aim of the study was to investigate smartphone addiction among technical institute nursing students: nomophobia and health. Subjects & Methods: Design: Descriptive design was used to conduct this study. Setting: The existing study was conducted in technical institute of nursing at Zagazig University. Sample: 360 students enrolled in the study. Tools: interview questionnaire, Smartphone Addiction Scale Short Version, Nomophobia Questionnaire, Neck Disability Index and Cornell Musculoskeletal Discomfort Questionnaire. Results: The results showed that 15% of Female Nursing Students with experienced of smartphone addiction compared with 13.33% among the male and more than half (58.06%) of the studied sample had moderate level of nomophobia. The highest mean score domain in the Neck Disability Index was headache (1.61±1.44), 37.50% of the studied sample had moderate musculoskeletal discomfort and 35% of them complained of blurred vision. Ultimately, there were statistically significant positive correlations between smartphone addiction, nomophobia, neck disability, musculoskeletal discomfort and eye problems. Conclusion: Smartphone addiction affects negatively on nomophobia and health. Recommendation: Nursing intervention program about hazards of smartphone addiction and its effects on health.