ABSTRACT A pot experiment was conducted at the Faculty of Technology and Development, Zagazig University, Sharkia Governorate, Egypt during 2018/2019 winter season to study the effect of integrated fertilization on the productivity of quinoa crop growing under calcareous soils. The experiment was laid out in split split plot arrangement using three replications. Main plots assigned to nitrogen fertilizers rates: N0, N1, N2, N3, N4, N5 & N6 (0.0, 75,100, 125 kg inorganic-N fed -1, 75 kg inorganic-N + 50 kg organic-N, 100 kg inorganic-N + 25 kg organic-N and 125 kg organic-N fed-1). The sub plots were dedicated to bio-fertilizer rates of b0, b1 (0.0 and 2 L fed-1). The sub-sub plots occupied to micronutrient rates of T0, T1 (0.0 and 2 L fed-1). The results indicated that the values of dry weight (DW), grain yield (GY), straw yield (SY), biological yield (BY), harvest index (HI), crude protein (CP), nitrogen (N), phosphorus (P) and potassium (K) uptakes by quinoa plant organs at flowering and harvest stage increased significantly with increasing bio- fertilizer rate, micronutrient rate and N rate up to 100 fed -1. Partial substitution of mineral nitrogen fertilizers (MNF) by organic nitrogen fertilizer (ONF) had positive effect on all vegetative characters and chemical composition. Interaction between studied factors gave positive effect on most studied traits. The best interaction treatment that achieved the highest values for most vegetative traits and chemical characters was (N2 × b1 × T1) or (N4 × b1 × T1).