Substrate Chain length specificity of Acyl-CoA dehydrogenase: Studies on different mutants. 13th International Congress of Flavins and Flavoprotiens, konstanz

Faculty Technology and Development Year: 1999
Type of Publication: ZU Hosted Pages:
Authors:
AbdulGhani AbdulHakeem AbdulGhani
Journal: In Flavins and flavoproteins Academic journal Volume:
Keywords : Substrate Chain length specificity , Acyl-CoA dehydrogenase:    
Abstract:
AcyJ-CoA dehydrogenases belong to a class of f1avoproteins that catalyse the desaturation of acyl-CoA substrates. The members of this family that are involved in mammalian mitochondrial ß-oxidation are classified according to their chain length specificity. Thus, the four presently known members are short-, medium-, long and very lang chain acyl-CoA dehydrogenases (SCADH, MCADH, LCADH, and VLCADH). A marked difference within this group concerns the location of the catalytically essential Glu that initiates catalysis. In LCADH it is found at pos. 255‏
    
     
 
       

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