Propranolol and carvedilol had a coloprotective effect against AA- induced colitis depending on their ability to decreases inflammation, oxidative stress state in rat colon. Carvedilol was better than propranolol and regarding the combination interaction, carvedilol combination synergized the ameliorative effects of mesalazine compared to mesalazine alone. Thus, carvedilol can be considered the β-blocker of benefit in UC treatment especially during treatment of other coexisting diseases indicated β-blockers. Additional clinical trials are advised to clarify their effectiveness in UC.