Stabilized-chitosan selenium nanoparticles efficiently reduce renal tissue injury and regulate the expression pattern of aldose reductase in the diabetic-nephropathy rat model

Faculty Veterinary Medicine Year: 2021
Type of Publication: ZU Hosted Pages: 119674
Authors:
Lymaa Labeb Mahmoud Ibrahiem
Journal: Life Sciences Elsevier Volume: 0024-3205
Keywords : Stabilized-chitosan selenium nanoparticles efficiently reduce renal    
Abstract:
One of the global alarming prevalent metabolic diseases is Type 2 diabetes mellitus (T2DM) than other diabetes and sustains a substantial burden on public and healthcare systems. This study attempts to endeavor the beneficial effect of chitosan stabilized nanoparticles Ch-SeNPs on combating diabetic nephropathy (DN) after induction of T2DM in rats (DN.STZ-induced T2D). High-fat diet (HFD) and STZ were used for the induction of T2DM in rats, and then they were treated with either metformin alone (MEF) (500 mg/kg b.wt.) or combined with (Ch-SeNPs) (2 mg Se/kg b.wt.) for eight weeks. The microvascular complications in renal tissue of diabetic rats were pronounced by the prevalence of microalbuminuria and elevated levels of urea, creatinine, and BUN. Pronounced oxidative stress with enhanced inflammatory response.
    
     
 
       

Author Related Publications

  • Lymaa Labeb Mahmoud Ibrahiem , "Structural changes in pigeon crop mucosa during crop milk secretion", كلية الطب البيطرى جامغة الزقازيق, 2013 More
  • Lymaa Labeb Mahmoud Ibrahiem , "Moderator Bands (Trabecula septomarginalis) of Mature Buffalo (Bos bubalis L.) with Special Emphasis on the Structure and Distribution of the Purkinje Cardiomyocytes: Histological and Histochemical", كلية الطب البيطرى جامغة الزقازيق, 2015 More
  • Lymaa Labeb Mahmoud Ibrahiem , "Structural insights of the glycogen body in domestic chicken", http://dx.doi.org/10.4172/ 2157-7099.1000391., 2016 More
  • Lymaa Labeb Mahmoud Ibrahiem , "Long-term intake of aspartame and hepatocellular injury in rabbits", zagazig university, 2016 More
  • Lymaa Labeb Mahmoud Ibrahiem , "Electromagnetic field induces cellular adaptation in the rat spinal cord ependyma", http://www.jofamerican science. org.1.doi:10.7537/marsjas12021601., 2015 More

Department Related Publications

  • Yasser Hosny Ali Elewa, "MRL/MpJ mice show unique pathological features after experimental kidney injury", Histol Histopathol (2016) 31: 189-204, 2016 More
  • Yasser Hosny Ali Elewa, "Rapid specimen preparation to improve the throughput of electron microscopic volume imaging for three-dimensional analyses of subcellular ultrastructures with serial block-face scanning electron microscopy", Med Mol Morphol (2016) 49:154–162, 2016 More
  • Maha Sabry El Sayed Kilani, "Effects of dietary Frankincense (Boswellia serrata) oil on growth, intestinal morphology, Fatty acid composition of breast muscles, Immune status, and immunoexpression of CD3 and CD20 in broiler chickens.", MDPI, 2023 More
  • Rasha Ragab Mahmoud Farag, "MACRO AND MICROSCOPICAL STUDIES ON THE PINEAL GLAND OF CAMEL WITH IMMUNOHISTOCHEMICAL LOCALIZATION TO PINEALOCYTES AND GLIA CELLS MARKERS.", International journal of advanced research, 2018 More
  • Yasser Hosny Ali Elewa, "Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1 alpha-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression", ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE, 2021 More
Tweet