The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase‑3 immunoexpression and oxidative damage induced by paracetamol in male rats

Faculty Veterinary Medicine Year: 2023
Type of Publication: ZU Hosted Pages: 30:41682–41699
Authors:
Lymaa Labeb Mahmoud Ibrahiem
Journal: Environ Sci Pollut Res Int. Springer Volume: 023-25152
Keywords : , palliative effect , mulberry leaf , olive leaf    
Abstract:
This study investigated the possible protective role of mulberry leaf (MLE) and olive leaf (OLE) ethanolic extracts against paracetamol (PTL)-induced liver injury in rats compared to silymarin as a reference drug. Initially, MLE and OLE were characterized using gas chromatography-mass spectrometry (GC/MS). Then, forty male Sprague Dawley rats were divided into five groups: the negative control group orally received distilled water for 35 days, the PTL-treated group (PTG) received 500 mg PTL/kg b. wt. for 7 days, the MLE-treated group (MLTG) received 400 mg MLE/kg b. wt., the OLE-treated group (OLTG) received 400 mg OLE/kg b. wt., and the silymarin-treated group (STG) received 100 mg silymarin/kg b. wt. The last three groups received the treatment for 28 days, then PTL for 7 days. The GC-MS characterization revealed that MLE comprised 19 constituents dominated by ethyl linoleate, phytol, hexadecanoic acid, ethyl ester, and squalene.
    
     
 
       

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