Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese Toxicity: Structural and Bioanalytical Approach in a Rat Model

Faculty Veterinary Medicine Year: 2018
Type of Publication: ZU Hosted Pages: 9
Authors:
Lymaa Labeb Mahmoud Ibrahiem
Journal: Biomedicine & Pharmacotherapy Elsevier Masson SAS Volume: 0753-3322
Keywords : Ebselen , Protect Male Reproductive Organs , Male    
Abstract:
Ebselen (EBS) is a versatile compound that can protect the cellular components from oxidative and free radical mediated damage. In the present study, we investigated the protective effect of EBS against manganese (Mn) toxicity on male reproductive organs. Thirty-two male rats were assigned into four groups, namely, negative control, EBS (15 mg/kg body weight (bw), as a single protective IP injection), MnCl2 (50 mg/kg bw, orally for 30 consecutive days), and EBS+MnCl2 (as mentioned before).
    
     
 
       

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