One of the most promising new avenues in eco-friendly analytical techniques is the creation of ion-selective electrodes (ISEs). Today, several techniques are being developed to create electrodes that are at once easy to use, very sensitive, long lasting, and remarkably stable. Here, an eco-friendly solid-state microfabricated copper electrode was constructed using readily available, low-cost copper printed circuit boards, and then a Prussian blue analogue (PBA) thin coating was applied for potentiometric determination of safinamide mesylate (SAF). The surface morphology, crystallinity and chemical structure of the produced PBA thin film were investigated using scanning electron microscopy (SEM), X-ray diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS) respectively. The proposed sensor was effectively implemented for the quantification of SAF in pure and pharmaceutical dosage form. There was no statistically significant difference between the results obtained using the suggested technique and the results obtained using the reported one. Also, green-metrics (including GAPI and the AGREE algorithm, which relies on 12 principles of green analytical chemistry) were used to provide a full evaluation of the investigated method greenness. Finally, the newly announced RGB12 model was used to compare the whiteness degree of the proposed and reported methods.