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An eco-friendly HPLC method for concurrent determination of carbocisteine, guaifenesin, and oxomemazine in their combined formulations
Faculty
Pharmacy
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Heba Mohamed Elsayed Ibrahym
Staff Zu Site
Abstract In Staff Site
Journal:
Talanta Open Elsevier
Volume:
Keywords :
, eco-friendly HPLC method , concurrent determination , carbocisteine,
Abstract:
The respiratory tract infections have a growing concern by healthcare specialists. Carbocisteine, guaifenesin, and oxomemazine are widely used as co-formulated anti-cough drugs. For the first time, a precise, accurate, and green HPLC method has been developed and validated for their determination in their combined dosage forms. The separation was accomplished using a photodiode array detector at 220 nm with an isocratic green mobile phase consisting of phosphate buffer 0.025 M, (pH 3) and ethanol (75:25, v/v) at a flow rate of 1.0 mL/min and ambient temperature. The developed method was validated in accordance with ICH guidelines. Carbocisteine, guaifenesin, and oxomemazine were separated in less than 12 min at 1.569 ± 0.005 min, 8.546 ± 0.007 min, and 10.877 ± 0.008 min, respectively. The linear ranges for carbocisteine, guaifenesin, and oxomemazine were 31.25–187.50, 25–150, and 0.5–3.0 µg/mL, respectively. The developed method can be used in quality control laboratories for the simultaneous determination of the investigated drugs in their pharmaceutical dosage forms. In addition, it proved its superiority over the reported methods in terms of greenness using different assessment tools.
Author Related Publications
Heba Mohamed Elsayed Ibrahym, "Rp-HPLC Determination of Quercetin in a Novel D-alpha-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma", MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2021
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Heba Mohamed Elsayed Ibrahym, "Determination of six drugs used for treatment of common cold by micellar liquid chromatography", Springer Berlin Heidelberg, 2021
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Heba Mohamed Elsayed Ibrahym, "Selective Determination of Nicorandil with a Single Planar Solid‐State Potentiometric Ion Selective Electrode", Wiley Analytical Science, 2021
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Heba Mohamed Elsayed Ibrahym, "New Instrumental Methods for Determination of some Pharmaceutical Compounds &Their A ", لايوجد, 1900
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Heba Mohamed Elsayed Ibrahym, "Quality by design approach for development and validation of a RP-HPLC method for simultaneous determination of co-administered levetiracetam and pyridoxine HCl in prepared tablets", Elsevier, 2018
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