Background: Psychiatric nursing are extraordinary areas in terms of interaction and communication with the patient. In order to progress patient care, psychiatric nurses ought to create their empathy skills. Nurses with improved empathetic capacities can get the understanding and give the essential care. Empathy is a basic component of great nursing care related with expanded patient fulfillment. Aim: This study aimed to investigate the effect of empathy-based training program on psychiatric nurses’ empathetic communication skills and burnout.Design: A quasi-experimental research design was used in the current study.Setting:This study was conducted at the Psychiatric Department inEl Salam Hospital, Zagazig University, Alsharkia Governorate. Subjects: A purposeful sample of 13 nursesin pre-test as sample well as in post-test. Tools:Four tools were used in this study: Socio demographic data sheet, Jefferson Scale of Empathy (JSE) Nursing Student Version R, Communication Skill Scale and Maslach Burnout Inventory (MBI). Results:Results denoted that the mean scores as regards knowledge about empathy and Maslach burnout were decreased from a pre-intervention to a post-intervention, while communication skillincreased from a pre-intervention to a post-intervention.There was a statistically significant difference between pre and post-intervention regarding knowledge about empathy. As well, there was a highly statistically significant difference between pre and post-intervention regarding Maslach Burnout Inventory.However, there was a statistically insignificant difference between pre and post-intervention regarding communication skill. Conclusion: This study concluded that empathy-based training program improved nurses’ communication skills and reduced burnout among psychiatric nurses. Recommendation:Carrying out continuous empathetic training programs is essential to all nurses to increase their empathetic skills. Keywords: Empathy, communication skills, burnout, psychiatric nursing