Background: Depression and suicide are increasing concern on cancer patients. Cancer represents the second leading cause of mortality in the world. Aim: To assess the prevalence of depression and suicidal behavior among cancer ill patients at Zagazig University Hospitals. Design: A cross sectional design was utilized in the current study. Setting: a sample of 513 cancer ill patients at 3 oncology out-patients clinic "the hematology clinic, Internal medicine tumor clinic and oncology and nuclear Medicine Clinic" at Zagazig University Hospitals. The tools used for data collection were Socio-demographic data sheet, Beck Depression Inventory (BDI-II) and Columbia Suicide Severity Rating Scale (C-SSRS).Results of the current study revealed that the prevalence of depression and suicide behavior among cancer patients was (30.4%) and (0%) respectively. There was no correlation between depression score and suicide score. The present study proven that depression is more common in patients with cancer. Depression increased by age, secondary level of education, single, retired, who had gastrointestinal tract, head and neck cancer. The oncology out patient's clinic must include multidisciplinary psychiatric team who are fully involved in each patient's management plan. Keywords: Cancer, Depression, Suicide