Abstract: Background: Employees' corrupt behaviors can be justified by citing organizational customs, values, and obligations. As a result, a true culture, justice, and devotion are important in any agency. Aim: Investigate the relationship among organizational corruption, culture, justice, and nurses’ attitude towards work at Zagazig University Hospitals (ZUH,s), Egypt. Design: A descriptive correlational design was adopted for this study. Subjects: A stratified random sample (n=377) of nurses from different classifications was selected. Data was collected using four tools, Organizational Corruption Scale, Organizational Culture Inventory, Organizational Justice Scale, and Nurses’ Attitude towards Work (Organizational Commitment type) Scale. Results: Revealed that, 72.5% of nurses reported that corruption practices occurred inside ZUH’s. Likewise, 74.8% & 71% of nurses had a positive perception of organizational culture and justice and only 75.3% of them had a high level of attitude toward work. Conclusion: Corruption was negatively associated with organizational culture, justice, and nurses' attitude towards work. Also, organizational culture, justice, and attitude toward work predicted the presence of corrupt practices. Recommendation: Authorities and nursing leaders must take a variety of steps to fight corruption, including enforcing policies and regulations, establishing an anti-corruption committee, systems for controlling, punishing transgressors, and rewarding honest conduct.