Background: Nurses are expected to be ready to acquire new skills and adopt new working styles to respond to changes. In this regard, determining the entrepreneurial tendency of nursing students and the factors that affect it will be useful during their transition into professional nursing. Aim: To examine the relationships among educational environment, future time perspective, career adaptability and entrepreneurial tendency of nursing students using career construction model of adaptation. Participants and methods: A simple random sample of 810 students from Faculty of Nursing, Zagazig University, Egypt. This study adopted descriptive correlational design; four tools were used to collect the data; The Dundee Ready Education Environment Measure, Future time perspective scale, University Students Entrepreneurship Scale, and Career Adapt-Ability Scale. Results revealed that 79.1 % and 50.4 % had had high level of future time perspective and career adaptability, respectively. 40.2% perceived their educational environment as poor and 56.1 % had low entrepreneurial tendency. Moreover, career adaptability was positively and significantly correlated with educational environment, future time perspective, and entrepreneurial tendency, where P-value < 0.05. Conclusion: career adaptability has full mediation in the relationships between educational environment, future time perspective and entrepreneurial tendency. Recommendation: Nursing schools and educators should provide career counseling for nursing students, encouraging them to be more FTP, offering them a supportive and positive educational environment. Also, courses that guide creative and innovative activities should be added in nursing curriculum.