Background: Nurses are the key professionals in healthcare sectors; their job attitudes are closely associated with patient health outcomes and safety. There is an increase in the expectations of organizations from their employees and similarly the expectations of employees from their organizations. Aim: assess relationships among organizational identification, cynicism, job demand- resources and nurses' job crafting. Subjects and methods: A stratified random sample of 345 staff nurses working in Zagazig University hospitals, Egypt. This study used descriptive correlational design. Four tools used to collect data; Job crafting questionnaire, Organizational identification scale, Organizational cynicism scale and Job demands-resources questionnaire. Results: revealed that slightly more than half of nurses reported high level of organizational identification, cynicism, job crafting and job resources (51%, 54.5%, 53.3% &50.4%, respectively), while 79.4% of them had high level of job demands. Organizational identification was significantly and positively correlated to nurses' job crafting, job resources and negatively correlated with job demands where P< 0.05. On the other hand, organizational cynicism was significantly and negatively correlated to nurses' job crafting, job resources and positively correlated to job demands where P< 0.05. Conclusion: Nurses' job crafting was significantly and positively correlated to organizational identification, while it was negatively correlated to cynicism. Unlike job demands and resources weren't correlated to job crafting. Recommendation: Healthcare organizations should take precautions to remove underlying factors that cause nurses to have a tendency to display cynical behaviors and inform them about the organization, provide in-service training, and help identify them with the organization and they can design targeted training programs that focus on empowering nurses with the tools needed to shape their jobs.