Background: Nursing students, the future nurses, are further inevitably providing healthcare for persons with disabilities (PWDs) in different care settings. The study aim was to explore nursing students' communication, attitude and willingness to care for persons with disabilities. Subjects and Methods: Design: A descriptive design was utilized. Subjects: A purposive sample of 452 undergraduate fourth-year nursing students. Settings: the study was carried out in Faculty of Nursing, Zagazig University, Egypt. Tool of data collection: Four tools were used including a questionnaire sheet of socio-demographic data, communication with disabled patients scale, attitude toward disabled person scale, and willingness to care for patients with disabilities scale. Results: The results revealed that 77.9% of the participants were females and 60.4% of them showed good communication with disabled people. Meanwhile, 51.1% of the students had positive attitude toward persons with disabilities and 49.3% of the nursing students had low level of willingness to care of them. Conclusion: Nursing students have good communication skills and more than half of them showed a positive attitude towards persons with disabilities while more than half of the students are unwilling to provide care for them. Recommendations: Educational interventions for nursing students before starting the internship year are crucial for enhancing their abilities to provide disability-related quality care to such vulnerable group.