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Co-administration of Thiophenicol and Antioxidants to protect Rat Bone Marrow and Testis
Faculty
Veterinary Medicine
Year:
2015
Type of Publication:
ZU Hosted
Pages:
Authors:
Sozaan Ahmed Ali esmaiel
Staff Zu Site
Abstract In Staff Site
Journal:
37th Scientific Conference of Egyptian Society. Conference of Egyptian Society.
Volume:
Keywords :
Co-administration , Thiophenicol , Antioxidants , protect , Bone Marrow
Abstract:
ABSTRACT Background: Thiophenicol (TAP) is a broad-spectrum synthetic antibacterial drug structurally similar to chloramphenicol. It widely used for the treatment of infectious diseases in humans and veterinary medicine. Recently, it has found as a feed additive for animal-breeding. However, administration of TAP has side effects on body organs especially bone marrow and testicular tissues have been proven scientifically. Aim of work: The aim of the current study is to mitigate thiophenicol’s side effects by using some antioxidant as spirulina and gensing. Material & Methods: One hundred and twenty eight male albino rats were divided into 8 groups for administrating with all possible combinations of the treatments consist of: control, thiophenicol (TAP), spirulina (SP), gensing (Gn) and their combinations. The rats were sacrificed after 14 days of treatments. The bone marrow and testis were fixed, and paraffin sections were stained. Results: The sole TAP treated rats showed a reduction in spermatogenesis and infiltrative inflammatory cells in the thicking intersitium between the seminefrous tubules of testis. In addition, single TAP treatments decreased erythropoiesis and increased the Myeliod:Erythriod ratio of bone marrow.TAP treated groups with SP and GN showed a slight change in bone marrow and testicular tissue compared with TAP group. The antioxidants groups have the normal histological structure similar to those of the control group. Conclusion: We concluded that spirulina and gensing have a potential positive action in mitigating the side effects of thiophenicol on bone marrow and testis of rats.
Author Related Publications
Sozaan Ahmed Ali esmaiel, "بعض الدراسات المجهرية على أعضاء تكوين الدم فى بعض أنواع الأسماك", لايوجد, 1900
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Sozaan Ahmed Ali esmaiel, "Dose- Related Impacts of Imidacloprid Oral Intoxication on Brain and Liver of Rock pigeon (Columba livia domestica), Residues Analysis in Different Organs", Elsevier, 2018
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Sozaan Ahmed Ali esmaiel, "Rectal, Anal Gland: A Corrective Morphological Study in New Zealand Rabbit (Oryctolagus cuniculus)", Journal of Vet. Med. Banha university, 2018
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Sozaan Ahmed Ali esmaiel, "Melamine and/or formaldehyde exposures affect steroidogenesis via alteration of StAR protein and testosterone synthetic enzyme expression in male mice", Elsevier, 2016
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Sozaan Ahmed Ali esmaiel, "Sublethal effect of fipronil exposure on liver and kidney tissues with evaluation of the recovery ability of Japanese quail (Coturnix japonica)", Hokkaido university, 2016
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Department Related Publications
Yasser Hosny Ali Elewa, "MRL/MpJ mice show unique pathological features after experimental kidney injury", Histol Histopathol (2016) 31: 189-204, 2016
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Yasser Hosny Ali Elewa, "Rapid specimen preparation to improve the throughput of electron microscopic volume imaging for three-dimensional analyses of subcellular ultrastructures with serial block-face scanning electron microscopy", Med Mol Morphol (2016) 49:154–162, 2016
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Maha Sabry El Sayed Kilani, "Effects of dietary Frankincense (Boswellia serrata) oil on growth, intestinal morphology, Fatty acid composition of breast muscles, Immune status, and immunoexpression of CD3 and CD20 in broiler chickens.", MDPI, 2023
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Rasha Ragab Mahmoud Farag, "MACRO AND MICROSCOPICAL STUDIES ON THE PINEAL GLAND OF CAMEL WITH IMMUNOHISTOCHEMICAL LOCALIZATION TO PINEALOCYTES AND GLIA CELLS MARKERS.", International journal of advanced research, 2018
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Yasser Hosny Ali Elewa, "Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1 alpha-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression", ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE, 2021
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