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Host and gut microbial metabolism of Bifidobacterium longum fermented rice bran in healthy mice and bioavailability of antimicrobial and cancer-protective compounds
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
hend Mohamed Mohamed Ibraheim
Staff Zu Site
Abstract In Staff Site
Journal:
Benef Microbes Wageningen Academic Publishers
Volume:
Keywords :
Host , , microbial metabolism , Bifidobacterium longum fermented
Abstract:
This study investigated gut microbiota composition along with food, host, and microbial derived metabolites in the colon and systemic circulation of healthy mice following dietary rice bran and fermented rice bran intake. Adult male BALB/c mice were fed a control diet or one of two experimental diets containing 10% w/w rice bran fermented by Bifidobacterium longum or 10% w/w non-fermented rice bran for 15 weeks. Metabolomics was performed on the study diets (food), the murine colon and whole blood. These were analysed in concert with 16S rRNA amplicon sequencing of faeces, caecum, and colon microbiomes. Principal components analysis of murine microbiota composition displayed marked separation between control and experimental diets, and between faecal and tissue (caecum and colon) microbiomes. Colon and caecal microbiomes in both experimental diet groups showed enrichment of Roseburia, Lachnospiraceae, and Clostridiales related amplicon sequence variants compared to control. Bacterial composition was largely similar between experimental diets. Metabolite profiling revealed 530 small molecules comprising of 39% amino acids and 21% lipids that had differential abundances across food, colon, and blood matrices, and statistically significant between the control, rice bran, and fermented rice bran groups. The amino acid metabolite, N-delta-acetylornithine, was notably increased by B. longum rice bran fermentation when compared to non-fermented rice bran in food, colon, and blood. These findings support that dietary intake of rice bran fermented with B. longum modulates multiple metabolic pathways important to the gut and overall health.
Author Related Publications
hend Mohamed Mohamed Ibraheim, "Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA. Am J Physiol Renal Physiol.: (porterJM, Ibrahim H, Taylor L, Curthoys NP(2006", لايوجد, 1900
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hend Mohamed Mohamed Ibraheim, "Renal response to metabolic acidosis: role of mRNA stabilization", لايوجد, 1900
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hend Mohamed Mohamed Ibraheim, "Complexity and species variation of the kidney-type glutaminase gene", لايوجد, 1900
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hend Mohamed Mohamed Ibraheim, "Complexity and species variation of the kidney-type glutaminase gene", لايوجد, 1900
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hend Mohamed Mohamed Ibraheim, "RNA recognition by 3?-to-5? exonucleases: The substrate perspective", لايوجد, 1900
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