Design, synthesis, in vitro and in silico evaluation of novel substituted 1,2,4-triazole analogues as dual human VEGFR-2 and TB-InhA inhibitors

Faculty Pharmacy Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Bioorganic Chemistry ELSEVIER Volume:
Keywords : Design, synthesis, , vitro , , silico evaluation , novel    
Abstract:
M. tuberculosis stimulates the macrophage to rapidly secrete vascular endothelial growth factor (VEGF) extracellularly so there is a relationship between tuberculosis and VEGF over secretion so this is my starting point in designing and synthesis of novel agents inhibit both tuberculosis and VEGFR-2 which have dual –antitubercular/anti cancer- activity.
   
     
 
       

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