Design, synthesis, in vitro and in silico evaluation of novel substituted 1,2,4-triazole analogues as dual human VEGFR-2 and TB-InhA inhibitors

Faculty	Pharmacy	Year:	2023
Type of Publication:	ZU Hosted	Pages:
Authors:	Staff Zu Site Abstract In Staff Site
Journal:	Bioorganic Chemistry ELSEVIER	Volume:

Keywords :	Design, synthesis, , vitro , , silico evaluation , novel
Abstract:	M. tuberculosis stimulates the macrophage to rapidly secrete vascular endothelial growth factor (VEGF) extracellularly so there is a relationship between tuberculosis and VEGF over secretion so this is my starting point in designing and synthesis of novel agents inhibit both tuberculosis and VEGFR-2 which have dual –antitubercular/anti cancer- activity.

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