Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective stud
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Marwa Zakaria Mohammed Mustafa
Staff Zu Site
Abstract In Staff Site
Journal:
ONCOLOGY LETTERS spandidos publications
Volume:
18
Keywords :
Tissue factor expression predicts outcome , children
Abstract:
. Previous studies have revealed that the processes of tumor angiogenesis, metastasis and invasiveness are highly dependent on components of the blood coagulation cascade. Tissue factor (TF) is one of the key proteins in coagulation. Cumulative evidence suggested that in addition to its role in coagulation, TF regulates intracellular signaling pathways that serve an important role in angiogenesis, tumor development and metastasis. In the present study, TF expression in neuroblastoma as well as its association with tumor stage, pathology and outcome were assessed. A total of 40 formalin-fixed paraffin-embedded tissues were evaluated for TF expression by immunohistochemical analysis. Results revealed that TF expression was positive in 75% of the analyzed tumor tissues. No significant association between TF expression and sex, age, tumor stage or disease pathology was observed. MYCN proto-oncogene bHLH transcription factor (MYCN) was upregulated in 45% (n=18) of the study cases. Positive TF expression was observed in 94.4% of patients (n=17) with upregulated MYCN, while 59% of patients (n=13) with normal MYCN showed positive TF expression (P<0.05). TF expression was a significant outcome predictor for patients; 18/30 patients (60%) with positive TF expression succumbed to the disease during the study period. In conclusion, TF may be a promising prognosis indicator for neuroblastoma. Future studies to determine how TF affects the progression and outcome of neuroblastoma, as well as to investigate its potential role as a therapeutic target, are required.
Author Related Publications
Marwa Zakaria Mohammed Mustafa, "Evaluation of the Immune Response to Interferon Gamma Release Assay and Tuberculin Skin Test Among BCG Vaccinated Children in East of Egypt A Cross-Sectional Study", Wolters Kluwer Health, Inc, 2016
More
Marwa Zakaria Mohammed Mustafa, "Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile", Wolters Kluwer Health, Inc, 2016
More
Marwa Zakaria Mohammed Mustafa, "First Report of Acute Lymphoblastic Leukemia in an Egyptian Child with b-Thalassemia Major", Hemoglobin, 2015
More
Marwa Zakaria Mohammed Mustafa, "Renal Presentation in Pediatric Acute Leukemia Report of 2 Cases", Medicine®, 2015
More
Marwa Zakaria Mohammed Mustafa, "Target Therapy in Neuroblastoma", INTECH, 2017
More
Department Related Publications
Lotfy Mohamed El Sayed Ali, "دراسة عن بعض السيتوكينات في حالات التسمم الدموي الميكروبي في الأطفال حديثي الولادة", لايوجد, 1900
More
Laila Raslan AbdulAziz, "دراسة وبائية ووراثية عن التشوهات الخلقية للقلب فى الاطفال", لايوجد, 1900
More
Laila Raslan AbdulAziz, "دراسة بعض الدلالات الكيميائية والاشعاعية لاعتلالات العظام فى انيميا البحر الابيض المتوسط ", لايوجد, 1900
More
Mervat Abdullah Hisham Hisham, "محاولة استقصاء دور طفيل التوكسوبلازما في الاعتلال المناعي لإلتهاب شبكية ومشيمية العين في الحالات البشرية .", لايوجد, 1900
More
Mervat Abdullah Hisham Hisham, "تأثير استبدال الدم على الشق الحر للأكسجين وبعض مضادات الأكسدة في الأطفال حديثي الولادة ", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف