Background: Endometriosis is a gynecological disorder identified by the presence of ectopic endometrial tissue outside the uterus. Largely, it affects reproductive-aged women and it is a major cause of infertility and chronic pelvic pain. Aim of the study was to evaluate the impact of educational nursing program on improving nonmedical students' awareness toward endometriosis at Zagazig University. Research design: A quasi- experimental design with pre/posttest and follow up was used in the current research. Setting: The study was conducted in two nonmedical faculties at Zagazig University. Subjects: 200 university non-medical female students were included in the study from the previously mentioned settings. Tools of data collection: Two tools were applied in the current study; Tool I: a structured interview questionnaire. Tool II: assessment of nonmedical students' awareness about Endometriosis (Pre/Post and follow up test). Results: A statistically significant improvements was observed in total level of awareness mean score after program implantation compared to its level before intervention, where it was 18.095±5.36 for the studied students in pretest which improved to 89.51±30.07and 74.77±35.88 at posttest and after one month of interventions respectively. Conclusion: Implementation of the educational nursing program had highly statistically significant effect on improving nonmedical students' awareness toward endometriosis at Zagazig University. Recommendations: Implementation of the educational nursing program with a learning booklet for nonmedical university female' students in various institutions should be conducted in order to increase their level of awareness related to endometriosis. Keywords: Nursing Program, Nonmedical students, Endometriosis, Students' awareness