Adropin is a peptide hormone involved in insulin sensitivity and cardiac function. The relationship of adropin and vascular functions is still in controversy, no available data demonstrated the effect of adropin on blood pressure. Objective: Demonstrating the effect of adropin on blood pressure in normal and induced hypertensive rats. Material and Methods: 48 male albino rats were divided into 6 groups: Control (C), Adropin treated (AT), Uninephrectomized (UNX), UNX-adropin treated (UNX+A), DOCA salt hypertensive (DOCA) and DOCA salt- adropin treated (DOCA+A). Results: Adropin reduced significantly systolic and diastolic pressures in both UNX+A group in comparison with UNX one (P< 0.0001) and in DOCA+A group (P< 0.0001) in comparison with DOCA group. Diastolic pressure was decreased significantly in adropin treated group (P< 0.05) in comparison with control group. Conclusion: According to available resources, this study is the first investigating the direct effect of adropin on blood pressure. Adropin decreased significantly diastolic pressure in both normal and induced hypertensive rats but reduced significantly systolic pressure only in hypertensive rats. Adropin might be a therapeutic agent in treatment of hypertension however, further studies on human are recommended.