Background: Lucilia silvarum Meigen,1826 (Diptera: Calliphoridae) is one of the medically important blowflies. Objective: This study aimed to estimate the toxicity of abamectin, deltamethrin and diazinon to eggs, larvae, and adult stages of L. silvarum. Moreover, the disturbances of some biological and physiological aspects were investigated. Materials and methods: Newly hatched eggs, early third instar larvae and one-day-old adult flies of L. silvarum were exposed to different concentrations of the selected insecticides. To follow some biological aspects of the tested concentration survivors such as egg hatchability, larval mortality, pupation %, adult emergence % and sex ratio were studied. Spectrophotometric estimation of total proteins, carbohydrates, lipids and certain enzymes activity were determined in the 3rd larval instar that survived the tested concentrations. Results: The results showed that abamectin provoked the highest toxicity value against the third larval instar, while deltamethrin elicited the most toxic effect against egg and adult stages. The mortality of eggs, larvae and adults increased with the increase of concentration. High significant larval and adult mortalities were observed after 48 h treatment. The percentage of pupation is reduced after treatment of the third larval instar with the three selected insecticides. A high significant reduction in the mean number of emerged males was observed after treatments with all concentrations of the three tested insecticides. The treatment with different concentrations of the investigated insecticides leads to physiological disturbances in total protein, carbohydrates and lipid contents of the treatment survived larvae. Moreover, the change in enzyme activities as MFOs, AChE, ALP, ACP, GST, α and β-estreases following insecticides application were measured. Conclusion: The three tested insecticides induced some biological and physiological disturbances in the life of survived insect pests which may be considered as control agents against the myiasis producing fly L. silvarum.