Bactrocera zonata (Saunders) flies are the dan-gerous insect pests of fruit, vegetables, and nuts over the world. This study provides the published in-formation on toxicity, biochemical effects and some biological measurements of the peach fly, B. zonata by using some plant extracts (phytochemicals) namely Moringa oleifera oil, lemon peel oil and M. oleifera leaf extract, which would be more informa-tive for publication facilitating related to integrated pest management (IPM) strategies of B. zonata. Effect of different concentrations of M. oleifera oil, lemon peel oil and M. oleifera leaf extract on bi-ochemical effects (total proteins, total carbohy-drates and acetylcholine esterase enzyme) and some biological aspects (pupal mortality, pupal du-ration, adult emergence, emerged deformed adult and malformation score) of the peach fly, B. zonata were studied. Results showed that M. oleifera oil is highly toxic to pupae of the peach fly, B. zonata with LC50 of 2.569, 2.773and 2.370ml/L and LC90 of 85.459, 92.171 and 18.314ml/L in yellow, sandy and clay soils respectively. Whereas lemon peel oil come in the second position in order of toxicity and M. oleifera leaf extract was the least toxic com-pound. These results cleared that concentrations of total proteins, total carbohydrates and acetylcholine esterase enzyme activity markedly decreased in pupae of B. zonata after exposure to M. oleifera oil, lemon peel oil and M. oleifera leaf extract with highly significant effects compared with control. Obtained results showed that an inhibitory action of M. oleif-era oil, lemon peel oil and M. oleifera leaf extract at all each of concentration levels when mixed with three types of soils namely, yellow soil, sandy soil and clay soil compared with untreated .These re-sults suggest that three tested plant extracts has the probably to be used as a natural plant productions to control of the peach fly, B. zonata.