Purpose: The aim of this study was to estimate the role of multidetector computed tomography (MDCT) in the evaluation of LV regional wall motion abnormalities (RWMA) in subjects complaining of coronary artery heart disease (CAD) and to compare MDCT data with two dimension standard echocardiography (2DSE) as the standard reference. Patients and Methods: Sixty subjects with supposed coronary artery heart disease were submitted to retrospective gating contrast-enhanced MDCT. 10 phases of the cardiac cycle were performed to detect end-systolic and end-diastolic phases at LV short-axis view. LV Regional wall motion was assessed qualitatively (visually in cine-mode) and quantitatively (measuring the percentage of systolic wall thickening on static end-diastolic and end-systolic images) on cardiac short-axis view and long-axis views using a 17-segment model. 2DSE was performed within two weeks before MDCT. Results: Good segmental agreement was found between echocardiography and MDCT (k=0.7; p < 0.001), MDCT detected 720 (98.7%) of 729 segments that showed normal motility, 172 (74.7%) of 230 segments showed hypokinesia and 49 (80.3%) of 61 segments showed akinesia or dyskinesia. Regarding the diagnostic performance, the sensitivity, specificity, and accuracy of MDCT reached 80.4%, 97.4%, and 93.5%, respectively, assuming 2DSE as the gold standard. Conclusion: Evaluation of regional left ventricular function by using MDCT is a precise method, with good agreement with 2D ECG. Key words: Coronary artery disease, regional left ventricular function, MDCT.