Background: Hepatology and midwifery nurses play a pivotal role in developing clinical and communication pathways between Hepatology and obstetric services. In addition to obstetric care antenatal, intranatal, and postnatal. The aim of this study was to: compare maternal and fetal outcome among pregnant women with hepatitis c virus infection and women without hepatitis c virus infection. Research design: A comparative research design “control group vs study group” was used to conduct the study from January 2021 to the end of July 2021. The study was carried out in obstetric department, labor ward in Maternity hospital at Mansoura University Hospital and New General Mansoura Hospital. A purposive sample composed of study “50 women” and control groups “50 women”. The tools used for data collection were: A structured interviewing questionnaire and Maternal and Fetal Assessment Sheet. The results of the present study revealed that there was a highly statistically significant difference between the two studied groups as regards the presence minor discomfort like heartburn. As regards progress of labor there was a statistically significant difference (p<0.05*) between both groups as regards membranes' condition (Chi-square=4.774). As for fetal and neonatal outcome there are statistically significant differences (p< 0.05*) between both groups as regard the Fetal heart rate, Respiration rate, Neonatal weight and NICU admission. Conclusion and Recommendation: Continuous education for women with hepatitis c about maternal and fetal outcome. There is need for illustrative booklet about self-care for women with hepatitis c during pregnancy and post natal period.