Barriers to evidence-based pressure ulcer prevention in Intensive Care Units Eman Mohammed Abd El-Aziz & Gehan El-Sayed Hafez Lecturers of Medical Surgical Nursing, Faculty of Nursing, Zagazig University Abstract: Aim of the study: The aim of the present study was to determine the barriers to evidence-based pressure ulcer prevention in Intensive Care Units. Research design and setting: A descriptive cross-sectional design was selected to conduct the current study in the ICU units of Zagazig University Hospitals. Subjects: 200 nurses from the above mentioned setting who met the inclusion criteria. Tools of data collection: A Self-administered questionnaire was used. Results: the majority of the nurses in the study sample (80%) were having unsatisfactory total knowledge about pressure ulcers. A great majority (90.5%) of the nurses in the study sample were having positive attitudes towards the prevention of pressure ulcers. slightly more than two-thirds of them (69.0%) were having high perception of barriers hindering the application of EBP in pressure ulcers management. It is noticed that the highest perceived barriers were related to the work environment (62%), whereas the lowest were related to nursing (11.5%). Conclusion: the main barriers to implementation of evidence-based preventive practices for pressure ulcers revealed in the study are the nurses’ deficient knowledge, in addition to the work environment-related barriers. Recommendations: training programs for nurses, improvement of work environment and further study for their effectiveness are recommended.