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In ovo protective effects of chicoric and rosmarinic acids against Thiaclopridinduced cytotoxicity, oxidative stress, and growth retardation on newly hatched chicks
Faculty
Science
Year:
2023
Type of Publication:
ZU Hosted
Pages:
14
Authors:
Susan Attia Moawad
Staff Zu Site
Abstract In Staff Site
Journal:
Poultry Science Elsevier Inc.
Volume:
Volume 102, Issue 4, April 2023, 102487
Keywords :
, , protective effects , chicoric , rosmarinic acids against
Abstract:
Thiacloprid (TH) is a neonicotinoid insecticide employed in agriculture to protect fruits and vegetables against different insects. It showed different deleterious effects on the general health of non-target organisms including birds and animals, however, its developmental toxicity has yet to be fully elucidated. Chicoric (CA) and rosmarinic (RA) acids are polyphenolic compounds with a wide range of beneficial biological activities. In this study, the possible protective effects of CA and RA were investigated in chick embryos exposed in ovo to TH (1mg/egg) with or without CA (100 mg/egg) or RA (100 mg/egg) co-exposure. TH reduced the hatchling body weight, body weight/egg weight, and relative weight of bursa of Fabricius in the one-day-old hatchlings. Examination of the 7-day-old chicks revealed a decline in feed intake, daily weight gain, feed conversion ratio (FCR), and plasma levels of T3, T4, and growth hormone. Serum ALT, AST activities, and total cholesterol levels showed significant elevations. Hepatic MDA was increased with a reduction in SOD activity and GSH level and downregulation of the liver SOD and GST gene expression pattern. Serum IgG and IgM levels were reduced, and various histopathological alterations were noticed in the liver. Co-administration of CA or RA with TH mitigated the toxic effects on hatchlings. When both CA and RA are combined, they present a synergistic protective effect. CA and RA can be used as protective agents against TH toxicity as they improve growth performance and have hepatoprotective and immunostimulant effects in newly hatched chicks.
Author Related Publications
Susan Attia Moawad, "A Comparative Morphological and Histological Study of the Olfactory Organ in Two Models of Bony Fishes (Mugil cephalus and Malapterurus electricus): A light and Electron microscopic study.", مجلة كلية العلوم, 2013
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Susan Attia Moawad, "Benefits of Chlorella vulgaris against Cadmium Chloride-Induced Hepatic and Renal Toxicities via Restoring the Cellular Redox Homeostasis and Modulating Nrf2 and NF-KB Pathways in Male Rats", MDPI, 2023
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Susan Attia Moawad, "In ovo protective effects of chicoric and rosmarinic acids against Thiacloprid-induced cytotoxicity, oxidative stress, and growth retardation on newly hatched chicks", Elsevier, 2023
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