Abstract Background: Breast cancer is considered the commonest cancer in Egyptian females. Established prognostic parameters of breast cancer patients are size, grade and stage of the tumor, presence of lymph nodes and distant metastasis in addition to assessment of hormonal receptors status. Aim of the current study was to assess ER, PR, Her2neu, Ki67 and AR status, to assess association between them, morphological and prognostic parameters in a large cohort of Egyptian females diagnosed with breast cancer. Patients and methods: This study was performed on 250 Egyptian female patients with breast cancer. All patients’ data were collected and statistically analyze all data for detection of the association between ER, PR, Her2-neu, Ki 67 labeling index, AR, clinicopathological and prognostic data. Results: we found an association between positive ER and positive PR, with low grade of the tumor, absence of lymphovascular invasion, little number of metastatic lymph nodes, early stage and absence of distant metastases, favorable survival rates and lower rate of recurrence and disease progression ( p<0.001). We found an association between positive AR, positive Her2-neu, high ki67 labeling index with; higher grade of the tumor, large number of metastatic lymph nodes and presence of distant metastases, unfavorable survival rates and higher rate of recurrence and disease progression ( p<0.001). Conclusion: expression of ER, PR and Her2neu could be considered other prognostic parameters for patients with breast cancer and must be routinely performed for all cases to detect the prognosis and expect progression of the tumor and survival rates. Keywords: Breast cancer, ER, PR, Her2neu, immunohistochemistry, Prognosis