The current study aimed at exploring the relationship among metacognitive factors, stress response, and anxiety, identifying metacognitive factors that predict anxiety, as well as revealing the relationship between stress response and anxiety when omitting the effect of metacognitive factors. The study sample consisted of (358) postgraduates (General diploma in Education) from Faculty of Education, Zagazig University aging (23 to 33), with mean age= 26.52 and standard deviation= 3.53. Study tools included Meta-cognitions Questionnaire MCQ, (Wells & Cartwright-Hatton, 2004), Stress Response Inventory SRI, (Koh et al., 2001), and The Penn State Worry Questionnaire PSWQ (Meyer, et al., 1990). Results revealed positive correlations between metacognitive factors and anxiety (except for cognitive self-awareness where the relationship was negative), metacognitive factors and stress response, and between stress response and anxiety. Only Negative Beliefs about worry predicted anxiety. The study results revealed a partial mediating role of metacognitive factors in the relationship between stress response and anxiety.