The current study aims at identifying the relationship between frustration and depression among university students. Furthermore, it aims at knowing the differences between genders as well as between disciplines (practical and theoretical) on frustration and depression scales. It also aims at revealing the dimensions of frustration predicting depression among university students. The sample consisted of 469 students (130 males - 339 females) from the fourth year of theoretical and practical colleges aged between (21 - 22) years old. The frustration scale (prepared by: the researcher) and the second Beck scale of depression (prepared by: Ghareeb Abd Al-Fatah 2015) were applied. The results concluded that: There is a statistically significant positive correlation between frustration scores (the dimensions and the total score) and the total scores of depression among the university students. There are statistically significant differences between the mean scores of the males and the females on the social frustration in favor of the females. There are statistically significant differences between the mean scores of the males and the females on the total score of depression in favor of the females. There are statistically significant differences between the mean scores of the practical and theoretical disciplines on both of the social and personal frustrations and the total score of the frustration in favor of the theoretical disciplines. There are statistically significant differences between the mean scores of the practical and theoretical disciplines on the total score of the depression in favor of the theoretical disciplines. The results also indicated that we can predict the total score of depression through the scores of academic, social, and personal frustrations from the dimensions of the frustration scale for university students. But, we can not predict the total score of depression through the scores of economic frustration.The study recommends the necessity of preparing courses and counseling programs to train university students on methods of coping with frustration they are exposed to and how to get out of frustration state without any harm to self or society and to protect them from depression.