Type 2 diabetes mellitus (T2DM) and thyroid dysfunctions are commonly observed concomitant endocrinopathies that have a common pathogenesis of insulin resistance. Also, adropin is a metabolic hormone that is secreted by many structures in the body. On the other hand, moderate exercise training was recorded to combat changes that occurred with obesity. But, the available information about the effect of type 2 diabetes mellitus on testicular function was contradictory and a scarce data was available on the effect of exercise training and adropin treatment on both thyroid and testicular functions in obese type 2 diabetic rats.