ABSTRACT Context: Nursing informatics is an important quality resource for patient care, which in effect promotes, enhances, and increases the organization's growth and influences the innovativeness level of the individuals. Aim: The aim of this study was to assess the relationship between nursing informatics competency and innovativeness among qualified nurses. Methods: Descriptive correlational cross-sectional study design used to conduct this study on all units (57 units) at Benha University Hospital, Egypt. A Convenience sample of all available (223) qualified nurses working at Banha University Hospital Nursing informatics competency assessment tool, and individual innovativeness (II) questionnaire. Results: 28% of the participants rated themselves as experts in the nursing informatics competency. While 40% and 22% were early adopters and innovators respectively regarding the total level of individual innovativeness. There was a positive, highly statistically significant correlation between the overall score of informatics competency and individual innovativeness for qualified nurses (r= 0.263, p value = 0.000). A highly statistically significant relationship also detected between the demographic variables in the study and both informatics competency and individual innovativeness for qualified nurses. Conclusion: A positive, highly statistically significant correlation evidenced between the overall score of informatics competency and individual innovativeness for qualified nurses. In order to prepare nursing students to meet the ever-changing technical needs of patients, computer and information skills should be integrated into the nursing curriculum. Also, nursing education programs should utilize educational methods that encourage innovativeness among their students. Keywords: Nursing informatics competency, innovativeness, and qualified nurses.