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Ameliorative Effect of Nigella Sativa on Tramadol-Induced Testicular Toxicity in Adult Rats
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Rania Saad Mohamed Ramadan
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Society for Clinical Toxicology Journal Egyptian Society of Clinical Toxicology
Volume:
Keywords :
Ameliorative Effect , Nigella Sativa , Tramadol-Induced Testicular
Abstract:
Background: Tramadol abuse is a major health problem in Egypt. It promotes oxidative stress via lowering the antioxidant levels. Nigella sativa (NS) possesses strong antioxidant properties. Objectives: the aim of the study was to assess the testicular toxicity after oral administration of tramadol, testicular recovery after tramadol withdrawal and the potential ameliorative effect of NS on tramadol-induced testicular impairment. Material and Methods: Sixty-six adult male rats were allocated into 4 groups: control group (divided into 3 subgroups orally received normal saline, corn oil, and NS dissolved in corn oil respectively), tramadol-treated group (40mg/kg/day for 30 days), recovery group left to recover for 2 weeks after 30 days of tramadol administration, and NS-co treated group administered NS (1ml/kg/day orally) along with tramadol. At the time of sacrifice, venous blood samples were obtained for assaying serum testosterone levels and the testes were processed for histological, morphometric and immunohistochemical examination. Results: Tramadol treatment resulted in deterioration of the testicular microarchitecture, intense expression of iNOS immunoreactivity, and statistically significant decreases in the tubular diameters, seminiferous epithelial heights, and serum testosterone levels. The recovery group revealed partial improvement of all the parameters tested. Co administration of NS significantly improved the detrimental testicular effects of tramadol; this improvement was clearer than that resulted from tramadol withdrawal, proving the protective role of NS. Conclusion: NS has a significant role in protection against tramadol-induced testicular damage. Recommendations: Tramadol should be administered only when indicated with appropriate dose monitoring. NS supplementation is also advisable in patients on tramadol therapy. Keywords: Tramadol, Nigella sativa, Testis, Inducible nitric oxide synthase.
Author Related Publications
Rania Saad Mohamed Ramadan, "Selenium Could Alleviate Potassium Dichromate-Induced Epididymal, Prostatic and Seminal Vesicle Changes in Adult Rats: Potential Role of Inhibiting NF-κB Pathway", Egyptian Society of Clinical Toxicology, 2023
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Rania Saad Mohamed Ramadan, "Moringa Oleifera Extract Could Ameliorate Aging-Related Structural and Functional Hepatic Changes by Regulating Autophagy Signaling Pathway", Wolters Kluwer Health, 2024
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Rania Saad Mohamed Ramadan, "Effect of Titanium Dioxide Nanoparticles on the Liver of Adult Male Albino Mice and Possible Protective Role of Carnosine", Egyptian Anatomical Society, 2017
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Rania Saad Mohamed Ramadan, "The potential anti‐osteoporotic effect of exercise—induced increased preptin level in ovariectomized rats", Springer Nature, 2022
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Rania Saad Mohamed Ramadan, "Comparing the Pancreatic and Pulmonary Protective Effects of Adropin and Dexamethasone on L-arginine Induced Acute Pancreatitis in Rats", Zagazig University, Faculty of Medicine, 2022
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Department Related Publications
Dalia Abdelhameed Mandour, "Effect of Induced Hypoglycemia on Postnatal Development of The Adrenal Gland in Albino Rats", British Journal of Scienc e, 2017
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Abdelmonem Awad Mostafa Hegazy, "COVID-19: Virology, Pathogenesis and Potential Therapeutics", Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020
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Dalia Abdelhameed Mandour, "Morphometric analysis of the orbit in adult Egyptian skulls and its surgical relevance", Eur. J. Anat, 2015
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Yousef Hussain Abdulaaty, "Histological Study of the Effect of Induced Diabetes on the Zona Glomerulosa of the Adrenal Cortex of Adult Male Albino Rat", Egypt J. Histol Vol. 33, No. 1, March, 2010:17-2, 2010
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Yousef Hussain Abdulaaty, "postnatal developmental changes of the parotid gland in albino rats: histological, immunohistochemical and morphometric study", British Journal of Science, 2014
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