Background: COVID-19 pneumonia is responsible for the latest pandemics. Chest computed tomography (CT) scanis known to be an essential tool for diagnosis of COVID-19. In this research, the relationship between on-admissionchest CT severity score, capillary blood oxygen saturation level, and laboratoryinflammatory markers results inpatients with SARS-COV-2 pneumonia wasinvestigated. Methods: This prospective analytical study was conducted in COVID-19 isolation unit, Zagazig University Hospitals,from 1st to end of April 2021. Adult patientswith COVID-19 infection were included. Chest CT scan was performed forall patients, and CT severity score was computed. The initial capillary oxygensaturation was also assessed at the timeof admission. The information wasgathered and analyzed. Results: A total number of 305 COVID-19 patients were involved in the study with the following data: age, gender,presence of co morbidities, capillary bloodoxygen saturation, laboratory tests including absolute lymphocytic count,CRP, D-dimer and ferritin levels, as well as chest CT severity score. Based on chest CTseverity score, we found that110 cases (36.1%) were mild, 163 cases (53.4%)were moderate, and 32 cases (10.5%) were severe, with significantmalepredominance among moderate and severe cases. The initial measurements ofblood oxygen saturation valuesrevealed that mean blood oxygen saturation was95.6% among mild to moderate cases and 85.4% among severecases. Furthermore, there was a high statistically significant negative correlation between chest CTseverity scoreand absolute lymphocytic count of studied cases, while there was astatistically significant positive correlation withD-dimer, CRP and ferritin levels. Conclusions: CT scans can help clinicians in developing a management strategy and serve as a predictor of illnessseverity and possible outcomes. In individualswith COVID-19 infection, the severity of a chest CT scan is positivelycorrelated to inflammatory markers and oxygen demand.