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SYNTHESIS OF SOME NEW DELTA-2-PYRAZOLINES, DELTA-2-ISOXAZOLINES AND 2-THIOPYRIMIDINE DERIVATIVES LIKELY TO POSSESS ANTIBACTERIAL ACTIVITY
Faculty
Science
Year:
1990
Type of Publication:
Article
Pages:
307-311
Authors:
BAYOUMY, BE, ELMOBAYED, M, ELBAHIE, S, ELLATIF, GA
Journal:
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN CHEM SOC PAKISTAN
Volume:
12
Research Area:
Chemistry
ISSN
ISI:A1990FV31800008
Keywords :
SYNTHESIS , SOME , DELTA-2-PYRAZOLINES, DELTA-2-ISOXAZOLINES , 2-THIOPYRIMIDINE DERIVATIVES
Abstract:
Benzalacetophenone derivatives (1) were allowed to react with thiourea to give tetrahydropyrimidine thione (2) which by reaction with acyl hydrazine or p-chlorobenzoyl hydrazine gave triazolopyrimidines (4) and (5) respectively. Compounds (1) were reacted with hydrazylamine hydrochloride or hydrazines to give the corresponding DELTA-2-isoxazolines (8) and DELTA-2-pyrazolines (9) respectively. The constitution of the novel compounds were proved by microanalysis, IR and mass spectral data.
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