viruses and their combined infections had bad outcome on the liver. Objective: To evaluate the risk of coinfection of the liver by both HCV, HBV and HIV on the liver outcome. Patients and Methods: This is a retrospective study of 241 patients attending different fever hospitals coinfected by HCV and or HBV with HIV but not HCV or HBV without HIV infections. Result: There was significant difference between male 59.8% and female 40.2%, age of patients, also there was significant difference as regard liver enzymes, cirrhosis, splenomegaly, international normalization ratio in triplet coinfections.