Background: The most typical solid benign uterine tumors are called uterine leiomyomas. The most prevalent gynecologic malignancy worldwide is endometrial cancer. It is mandatory to search for new markers that could facilitate early diagnosis and prognosis of endometrial cancer biopsy specimens; among these are Glut-1, and progesteron receptor (PR). Aim: To investigate if there is relation between uterine leiomyoma and the associated benign or malignant endometrial lesions. Materials and methods: This study included 109 patients who underwent a total abdominal hysterectomy, the specimens were fixed in 10% formalin solution and sent to Pathology Department, Faculty of Medicin, Zagazig University and processed for histological routine H&E investigation. Patients were divided into: GI (control group) and included 24 patients diagnosed with uterine leiomyomas with normal endometrium, GII included 60 patients diagnosed with uterine leiomyoma associated with endometrial carcinoma, and GIII included 25 patients diagnosed with uterine leiomyoma associated with atypical endometrial hyperplasia. Results: Patients with leiomyoma associated with endometrial cancer and coupled negative PR expression were substantially linked with high GLUT-1 expression 26. Conclusion: High GLUT-1 and low PR expression in leiomyomas could serve as useful additional marker in predicting the increased future risk of hyperplastic atypia and malignancy and differentiate benign endometrium from atypically hyperplastic endometrium.