Egypt COVID-19: Assessment of Knowledge, Attitudes and Practices among the General Population: Cross-Sectional Study Yasmin Husseiny Hassan Hussein1 1Department of Family Medicine, Faculty of Medicine, Zagazig University. Abstract: Background: Egypt has adopted exceptional preventive measures to control COVID-19. People's knowledge, attitudes, and practices towards this health problem influences their compliance with preventive strategies. Objectives: The present research assesses the level of knowledge, attitudes, and practices (KAP) regarding COVID-19 among the general population in Sharkia Governorate, Egypt. Methods: A cross-sectional survey was performed between May 28 and June 11, 2020. The respondents were invited to fulfill and submit an online survey created by Google Forms. The knowledge questionnaire included 13 items related to symptoms, transmission, and preventive measures of the disease. The participants’ attitudes and practices included questions about their confidence in Egypt if it will win the fight against COVID-19 as well as the appropriate hand washing measures. Results: The mean knowledge score was 11.16, and the correct response rate for the knowledge questionnaire was 85.8%. More than half of the participants were confident that Egypt will win the fight against the disease. Also, most of them practice appropriate hand washing measures. The average knowledge score was significantly lower among older, low education, rural, non-working, and low socioeconomic groups. Multivariate logistic regression analyses revealed that the COVID-19 knowledge score (OR: 0.72-1.16, P<0.001) was significantly linked to a reduced probability of non-optimistic attitudes and unhealthy practices regarding COVID-19. Conclusions: Overall, the participants had a high level of knowledge, sound practices, and were not optimistic concerning COVID-19. More efforts are needed to focus the health education strategies on the low-knowledge groups reported in this study. Keywords Hand washing, Mask, Pandemic, Prevention