The reuse of the various industrial wastes or by-products had become a general trend all over the world in order to prevent, or at least to reduce the environment pollution. Cement Kiln Dust (CKD) and Fly Ash (FA) considered as no-cost material and are used as a sludge conditioner, stabilizing chemical, and also used to improve the quality of wastewater treatment and irrigation water, thus, the present study was aimed to investigated the effect of different types of traditional coagulant and byproduct materials on Bahr El-Baqar drainage water properties for safe reusing of treated effluent in agricultural purposes and irrigation. The used optimum dose of coagulants and effect of polymer was determined using standard jar test; the optimum dose was 40, 30, 300, and 100 mg/l for Alum, Ferric Chloride, CKD and FA respectively. FA was the most effective coagulant for the removal of Biological oxygen demand (BOD) and Chemical oxygen demand (COD) while for Total Suspended Solids (TSS) almost all tested coagulants have the same removal ratio with small superiority for Ferric Chloride. Addition of polymer enhanced the performance of all test coagulant and the removal of TSS reached 90%, 92%, 86% and 93% for Alum, Ferric Chloride, CKD and FA respectively at a dose of 1 mg/l, according to the performed technical and economical comparison the recommended order of the coagulant is FA, Ferric Chloride, CKD and Alum.